中西医结合学院

School of Integrative Medicine.

吕爱平 院长

发布者：中西医发布时间：2021-11-25浏览次数：1340










吕爱平，讲座教授，上海市中医药研究院关节炎研究所所长、名誉所长，香港浸会大学中医药学院院长

通讯地址：香港九龙塘，香港浸会大学中医药学院



Aiping Lv, Chair professor,

Honorary Director of Arthritis Research Institute, Shanghai Academy of Traditional Chinese Medicine; The Dean of School of Chinese Medicine, Hong Kong Baptist University

Address: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong


学习和工作经历

  • 2014.12起 上海中医药大学教授、中西医结合研究院院长（2019）

  • 2012.07–至今 上海市中医药研究院关节炎研究所所长、名誉所长（2020）

  • 2012.02起 香港浸会大学中医药学院院长、Dr. Kennedy Wong 冠名讲座教授

  • 1994.09-1997.07 中国中医研究院获得博士学位

  • 1984.09-1987.07 中国中医研究院获得硕士学位

  • 1978.12-1983.12 江西中医学院获得学士学位


Education and Research experiences

  • 2019-present, Dean, Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine

  • 2014.12-present, Professor, Shanghai University of Traditional Chinese Medicine

  • 2012.02-present, Dean and Dr. Kennedy Wong endowed professor, School of Chinese Medicine, Hong Kong Baptist University

  • 1994.09-1997.07, M.D. China Academy of Traditional Chinese Medicine

  • 1984.09-1987.07, M.M. China Academy of Traditional Chinese Medicine

  • 1978.12-1983.12, M.Bc. Jiangxi University of Traditional Chinese Medicine


研究领域

  • 疾病证候分类与中医临床评价方法研究

  • 骨与关节疾病的新药开发

  • 中药治疗自身免疫性疾病的作用机理

Research area

  • Classification of Traditional Chinese Medicine syndromes and clinical evaluation strategy of Traditional Chinese Medicine

  • New drug development for bone and joint diseases

  • The mechanistic action of Traditional Chinese Medicine in the treatment of autoimmune diseases


研究成果及获奖

  • 获得国家、省市级科研奖励 50项

  • 申报药物相关发明专利95项


Achievements and Awards

  • Obtained 50 national, provincial and municipal scientific research awards

  • Declared 95 drug-related invention patents


主要社会兼职

  • 全国政协参政议政人才库首批特聘专家

  • 最高人民检察院特约检查员

  • 第十一届、第十二届全国政协委员

  • 药典委员会委员（名词术语委员会、中医专业委员会）

  • 国际中医药规范化研究协会主席GP-TCM RA 主席

  • Frontier in Pharmacology杂志副主编

  • WHO ICD-11 (TM) 专家成员

  • ISO-TC249中方代表团团长

  • 香港食品卫生局研究委员会成员

  • 香港中医中药发展委员会委员

  • 香港中医药管理委员会委员

  • 香港中药研究与发展委员会委员

  • 澳门科技基金项目顾问

  • 第十一届北京市政协委员


Social positions

  • The first batch of specially-appointed experts of the CPPCC National People's Political Consultative Conference

  • Special Inspector of the Supreme People's Procuratorate

  • The Member of the 11th and 12th National Committee of the Chinese People's Political Consultative Conference

  • Member of the Pharmacopoeia Committee

  • Expert member of WHO ICD-11 (TM)

  • The Head of the Chinese delegation of ISO-TC249

  • Research Council member of Food and health Bureau, Hong Kong

  • Member of Hong Kong Chinese Medicine Development Committee

  • Member of the Hong Kong Chinese Medicine Council

  • Member of Hong Kong Chinese Medicine Research and Development Committee

  • Macau Science and Technology Fund Project Consultant

  • Member of the 11th Beijing CPPCC


基金主持及参与

  • 主持国家自然科学基金、省基金和香港RGC项目累积57项

  • 参与战略规划研究项目17项

  • 2008年国家杰出青年科学基金资助


Grant Funding

  • Granted over a total of 57 projects from the National Natural Science Foundation of China, Provincial Funds and Hong Kong RGC funds as PI

  • Participated in 17 national strategic planning research projects

  • Received the National Science Fund for Distinguished Young Scholars in 2008


代表论文（Publication）

1.ZY Yang, J Dong, ZJ Yang, M Yin, HL Jiang, AP Lu, X Chen, TJ Hou, DS Cao. ChemFLuo: a web-server for structure analysis and identification of fluorescent compounds. Briefings in Bioinformatics (IF=11.6) 2020

2.ZY Yang, ZJ Yang, AP Lu, TJ Hou, DS Cao. Scopy: an integrated negative design python library for desirable HTS/VS database design. Briefings in Bioinformatics(IF=11.6) 2020

3.H Zhao, A Lu, X He. Roles of MicroRNAs in Bone Destruction of Rheumatoid Arthritis. Frontiers in Cell and Developmental Biology (IF=6.7) 8, 1349

4.YQ Deng, H Luo, J Shu, H Shu, C Lu, N Zhao, Y Geng, X He, A Lu. Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice. Chinese Medicine (IF=5.4) 15, 1-9

5.D Fan, C Liu, L Li, C Lu, N Zhao, J Shu, X He, A Lu. Deciphering Antitumor Mechanism of Pien Tze Huang in Mice of Hepatocellular Carcinoma Based on Proteomics. Journal of Immunology Research (IF=4.8) 2020

6.Zhong, L.L.D., Kun, W., Shi, N., Ziea, T.C., Ng, B.F.L., Gao, Y., Bian, Z., Lu, A. Evidence-based Chinese Medicine Clinical Practice Guideline for Stroke in Hong Kong. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1)

7.Wong, K.H., Xie, Y., Huang, X., Kadota, K., Yao, X.-S., Yu, Y., Chen, X., Lu, A., Yang, Z. Delivering Crocetin across the Blood-Brain Barrier. by Using γ-Cyclodextrin to Treat Alzheimer’s Disease. (2020) Scientific Reports (IF=4.3), 10 (1)

8.Wei, H., Guan, Y.-D., Zhang, L.-X., Liu, S., Lu, A.-P., Cheng, Y., Cao, D.-S. A combinatorial target screening strategy for deorphaning macromolecular targets of natural product. (2020) European Journal of Medicinal Chemistry (IF=6.5), 204.

9.Shi, Y., Shu, H., Wang, X., Zhao, H., Lu, C., Lu, A., He, X. Potential Advantages of Bioactive Compounds Extracted From Traditional Chinese Medicine to Inhibit Bone Destructions in Rheumatoid Arthritis. (2020) Frontiers in Pharmacology (IF=5.8), 11.

10.Gao, Y., Wang, K.-X., Wang, P., Li, X., Chen, J.-J., Zhou, B.-Y., Tian, J.-S., Guan, D.-G., Qin, X.-M., Lu, A.-P. A Novel Network Pharmacology Strategy to Decode Mechanism of Lang Chuang Wan in Treating Systemic Lupus Erythematosus. (2020) Frontiers in Pharmacology(IF=5.8), 11

11.Zhao, Y., Zhang, L.-X., Jiang, T., Long, J., Ma, Z.-Y., Lu, A.-P., Cheng, Y., Cao, D.-S. The ups and downs of Poly(ADP-ribose) Polymerase-1 inhibitors in cancer therapy–Current progress and future direction. (2020) European Journal of Medicinal Chemistry (IF=6.5), 203.

12.Ye, W.-L., Shen, C., Xiong, G.-L., Ding, J.-J., Lu, A.-P., Hou, T.-J., Cao, D.-S. Improving docking-based virtual screening ability by integrating multiple energy auxiliary terms from molecular docking scoring. (2020) Journal of Chemical Information and Modeling (IF=4.9), 60 (9), pp. 4216-4230.

13.Chowdhury, D., Wang, C., Lu, A., Zhu, H. Identifying Transcription Factor Combinations to Modulate Circadian Rhythms by Leveraging Virtual Knockouts on Transcription Networks. (2020) iScience (IF=5.1). 23 (9)

14.Gadau, M., Zhang, S.P., Wang, F.C., Liguori, S., Li, W.H., Liu, W.H., Bangrazi, S., Berle, C., Razavy, S., Bian, Z.X., Filomena, P., Hao, Y., Jiang, H.L., Lei, L., Li, T., Zaslawski, C., Liguori, A., Liu, Y.S., Lu, A.P., Tan, Y.S., Yim, W.W., Xie, C.L. A multi-center international study of acupuncture for lateral elbow pain - Results of a randomized controlled trial. (2020) European Journal of Pain (United Kingdom) (IF=3.9), 24 (8), pp. 1458-1470.

15.Wong, K.H., Lu, A., Chen, X., Yang, Z. Natural ingredient-based polymeric nanoparticles for cancer treatment. (2020) Molecules (IF=4.4), 25 (16).

16.Guo, Q., Li, L., Zheng, K., Zheng, G., Shu, H., Shi, Y., Lu, C., Shu, J., Guan, D., Lu, A., He, X. Imperatorin and β-sitosterol have synergistic activities in alleviating collagen-induced arthritis. (2020) Journal of Leukocyte Biology (IF=4.9), 108 (2), pp. 509-517.

17.Wang, K.-X., Gao, Y., Lu, C., Li, Y., Zhou, B.-Y., Qin, X.-M., Du, G.-H., Gao, L., Guan, D.-G., Lu, A.-P. Uncovering the Complexity Mechanism of Different Formulas Treatment for Rheumatoid Arthritis Based on a Novel Network Pharmacology Model. (2020) Frontiers in Pharmacology(IF=5.8), 11.

18.Zhuo, Z., Wan, Y., Guan, D., Ni, S., Wang, L., Zhang, Z., Liu, J., Liang, C., Yu, Y., Lu, A., Zhang, G., Zhang, B.-T. A Loop-Based and AGO-Incorporated Virtual Screening Model Targeting AGO-Mediated miRNA–mRNA Interactions for Drug Discovery to Rescue Bone Phenotype in Genetically Modified Mice. (2020) Advanced Science (IF=16.8), 7 (13)

19.Wu, X., Li, F., Li, Y., Yu, Y., Liang, C., Zhang, B., Zhao, C., Lu, A., Zhang, G. A PD-L1 aptamer selected by loss-gain cell-SELEX conjugated with paclitaxel for treating triple-negative breast cancer (2020) Medical Science Monitor (IF=2.64), 26.

20.Li, L.-F., Wong, T.-L., Zhang, J.-X., Zhou, L.-S., Bai, S.-P., Fung, H.-Y., Cheng, H.-Y., Zhang, Q.-W., Zheng, H.-M., Bao, W.-R., Ma, D.-L., Leung, C.-H., Zhang, G., Bian, Z.-X., Lyu, A.-P., Han, Q.-B. An oligosaccharide-marker approach to quantify specific polysaccharides in herbal formula by LC-qTOF-MS: Danggui Buxue Tang, a case study. (2020) Journal of Pharmaceutical and Biomedical Analysis (IF=3.9), 185.

21.Gong, M., Ye, S., Li, W.-X., Zhang, J., Liu, Y., Zhu, J., Lv, W., Zhang, H., Wang, J., Lu, A., He, K. Regulatory function of praja ring finger ubiquitin ligase 2 mediated by the P2rx3/P2rx7 axis in mouse hippocampal neuronal cells. (2020) American Journal of Physiology - Cell Physiology(IF=4.2), 318 (6), pp. C1123-C1135.

22.Yang, Z.-Y., He, J.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Application of negative design to design a more desirable virtual screening library. (2020) Journal of Medicinal Chemistry (IF=7.4), 63 (9), pp. 4411-4429.

23.Yang, Z.-Y., Dong, J., Yang, Z.-J., Lu, A.-P., Hou, T.-J., Cao, D.-S. Structural Analysis and Identification of False Positive Hits in Luciferase-Based Assays. (2020) Journal of chemical information and modeling (IF=4.9), 60 (4), pp. 2031-2043.

24.Yang, Z.-Y., He, J.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Frequent hitters: nuisance artifacts in high-throughput screening. (2020) Drug Discovery Today (IF=6.3), 25 (4), pp. 657-667.

25.Chuanxin, Z., Shengzheng, W., Lei, D., Duoli, X., Jin, L., Fuzeng, R., Aiping, L., Ge, Z. Progress in 11β-HSD1 inhibitors for the treatment of metabolic diseases: A comprehensive guide to their chemical structure diversity in drug development. (2020) European Journal of Medicinal Chemistry (IF=6.5), 191

26.Deng, Y., Luo, H., Shu, J., Shu, H., Lu, C., Zhao, N., Geng, Y., He, X., Lu, A. Pien Tze Huang alleviate the joint inflammation in collagen-induced arthritis mice. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1).

27.Zhang, Y., Zhao, H., Liu, B., Li, L., Zhang, L., Bao, M., Ji, X., He, X., Yi, J., Chen, P., Lu, C., Lu, A. Low Level Antibodies Against Alpha-Tropomyosin Are Associated With Increased Risk of Coronary Heart Disease. (2020) Frontiers in Pharmacology (IF=5.8), 11.

28.Wu, X., Li, F., Dang, L., Liang, C., Lu, A., Zhang, G. RANKL/RANK System-Based Mechanism for Breast Cancer Bone Metastasis and Related Therapeutic Strategies. (2020) Frontiers in Cell and Developmental Biology (IF=6.7), 8.

29.Zhang, X., Tian, R., Lam, W.C., Duan, Y., Liu, F., Zhao, C., Wu, T., Shang, H., Tang, X., Lyu, A., Bian, Z. Standards for reporting interventions in clinical trials of cupping (STRICTOC): Extending the CONSORT statement. (2020) Chinese Medicine (United Kingdom) (IF=4.5), 15 (1)

30.Fu, L., Liu, L., Yang, Z.-J., Li, P., Ding, J.-J., Yun, Y.-H., Lu, A.-P., Hou, T.-J., Cao, D.-S. Systematic Modeling of log D7.4 Based on Ensemble Machine Learning, Group Contribution, and Matched Molecular Pair Analysis. (2020) Journal of Chemical Information and Modeling (IF=4.9), 60 (1), pp. 63-76.

31.Zhao, L., Yang, W., Chen, Y., Huang, F., Lu, L., Lin, C., Huang, T., Ning, Z., Zhai, L., Zhong, L.L.D., Lam, W., Yang, Z., Zhang, X., Cheng, C., Han, L., Qiu, Q., Shang, X., Huang, R., Xiao, H., Ren, Z., Chen, D., Sun, S., El-Nezami, H., Cai, Z., Lu, A., Fang, X., Jia, W., Bian, Z. A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome. (2020) Journal of Clinical Investigation (IF=14.8), 130 (1), pp. 438-450.

32.Zhang, H., Lu, J., Liu, J., Zhang, G., Lu, A. Advances in the discovery of exosome inhibitors in cancer. (2020) Journal of Enzyme Inhibition and Medicinal Chemistry (IF=5.0), 35 (1), pp. 1322-1330.

33.Zhong, L.L.D., Shi, N., Sun, Y., Ng, B.F.L., Bian, Z., Lu, A. Hong Kong Chinese medicine clinical practice guideline for insomnia. (2020) European Journal of Integrative Medicine (IF=6.5).

34.Yang, S.-Q., Ye, Q., Ding, J.-J., Ming-Zhu, Y., Lu, A.-P., Chen, X., Hou, T.-J., Cao, D.-S. Current advances in ligand‐based target prediction. Wiley Interdisciplinary Reviews: Computational Molecular Science (IF=16.77), e1504

35.Cao, Z., Li, W., Liu, R., Li, C., Song, Y., Liu, G., Chen, Y., Lu, C., Lu, A., Liu, Y. Ph-responsive fluorescence enhanced nanogel for targeted delivery of aur and cddp against breast cancer. (2020) International Journal of Nanomedicine (IF=6.4), 15, pp. 8369-8382.

36.Cui, H., Shu, H., Fan, D., Wang, X., Zhao, N., Lu, C., Lu, A., He, X. Wang-Bi Capsule Alleviates the Joint Inflammation and Bone Destruction in Mice with Collagen-Induced Arthritis. (2020) Evidence-based Complementary and Alternative Medicine (IF=2.6), 2020.

37.Liu, L., Liu, Z., Li, H., Cao, Z., Li, W., Song, Z., Li, X., Lu, A., Lu, C., Liu, Y. Naturally occurring TPE-CA maintains gut microbiota and bile acids homeostasis via FXR signaling modulation of the liver-gut axis. (2020) Frontiers in Pharmacology (IF=5.8), 11

38.Ni, S., Zhuo, Z., Pan, Y., Yu, Y., Li, F., Liu, J., Wang, L., Wu, X., Li, D., Wan, Y., Zhang, L., Yang, Z., Zhang, B.-T., Lu, A., Zhang, G. Recent Progress in Aptamer Discoveries and Modifications for Therapeutic Applications. (2020) ACS Applied Materials and Interfaces (IF=9.2)