• 情志病的中医病因病机证治规律研究

随着现代社会生活节奏不断加快、竞争压力不断加剧，抑郁症、焦虑症、躁郁症等慢性应激性疾病的患病率持续上升。应激反应是生物在长期进化过程中形成的基本生存机制之一，根据其持续时间、作用强度以及对机体的影响，主要分为急性应激和慢性应激两种类型，其中慢性应激对心理和生理健康有着不良影响。中医情志理论认为，慢性应激性疾病如抑郁症、焦虑症的发生发展与情志失调密切相关。情志是机体脏腑精气受各种内外因素刺激发生变动，并通过心神感应而产生的具有某种倾向性的心理和精神活动。适度的情志变动有利于脏腑功能调和，而长期的情志失调则会导致疾病的发生发展。通过系统梳理总结中医情志理论的相关文献，旨在初步阐明情志病的中医病因病机证治规律。

• 中医药调节情志应激抗肿瘤的作用机制研究

在中医情志理论的指导下，结合肿瘤患者的临床证候特点和动物实验研究结果，我们选择逍遥散和小柴胡汤两首中医经典方剂进行研究。逍遥散是中医调和肝脾、疏肝解郁的名方，该方出自宋代《太平惠民和剂局方》，由“柴胡一两、当归一两、茯苓一两、白芍一两、白术一两、炙甘草半两、薄荷少许、煨生姜一块”组成，主治“血虚劳倦，五心烦热，……荣卫不和，痰嗽潮热，肌体羸瘦，渐成骨蒸。”临床上广泛运用于肝郁脾虚型抑郁症、焦虑症等精神心理疾病的治疗。小柴胡汤是和解少阳的代表方剂之一，首见于《伤寒杂病论》，由柴胡半斤、黄芩三两、人参三两、半夏半升、炙甘草三两、生姜三两、大枣十二枚组成，主治“伤寒五六日，中风，往来寒热，胸胁苦满，嘿嘿不欲饮食，心烦喜呕，或胸中烦而不呕，或渴，或腹中痛，或胁下痞鞕，或心下悸，小便不利，或不渴，身有微热，或欬者，小柴胡汤主之。”

• 中西医结合防治脑卒中

脑卒中又称“中风”、“脑血管意外”，是一种急性脑血管疾病，是由于脑部血管突然破裂或因血管阻塞导致血液不能流入大脑而引起脑组织损伤的一组疾病，包括缺血性卒中和出血性卒中。颈内动脉和椎动脉闭塞和狭窄可引起缺血性脑卒中。出血性卒中的死亡率较高。相关调查显示，城乡合计脑卒中已成为我国第一位死亡原因，也是中国成年人残疾的首要原因，脑卒中具有发病率高、死亡率高和致残率高的特点。中西医结合防治脑卒中具有独特的优势，我们将中医“天人合一”、“三因制宜”、“治未病”的整体观应用于脑卒中的防治中，将临床研究与基础研究有机结合，旨在进一步降低病残率，减少社会和家庭经济负担。

• Study on the Law of Pathogenesis, Syndrome and Treatment of Emotional Diseases in Traditional Chinese Medicine

With the accelerating pace of life and increasing competitive pressure in modern society, the prevalence of chronic stress diseases such as depression, anxiety disorder and bipolar disorder continues to rise. Stress response is one of the basic survival mechanisms formed in the long-term evolution of organisms. According to its duration, action intensity and impact on the body, it is mainly divided into acute stress and chronic stress. Chronic stress has adverse effects on mental and physical health.According to the emotional theory of traditional Chinese medicine, the occurrence and development of chronic stress diseases such as depression and anxiety are closely related to emotional disorders. Emotion is a psychological and spiritual activity with a certain tendency, which is stimulated by various internal and external factors and produced by mind and spirit induction. Moderate emotional changes are conducive to the reconciliation of visceral functions, while long-term emotional disorders will lead to the occurrence and development of diseases. By systematically combing and summarizing the relevant literature of TCM emotion theory, we aim to clarify the TCM etiology, pathogenesis, syndrome and treatment law of emotion diseases.

• Study on the anti-tumor mechanisms of traditional Chinese medicine regulating emotional stress

Under the guidance of TCM emotion theory, combined with the clinical syndrome characteristics of tumor patients and the results of animal experimental research, we chose Xiaoyao Powder and Xiaochaihu Decoction to study. Xiaoyao Powder is a famous prescription of traditional Chinese medicine for harmonizing the liver and spleen, soothing the liver and relieving depression. It comes from the prescription of Taiping Huimin Heju in the Song Dynasty. Xiaochaihu Decoction is one of the representative prescriptions for reconciling Shaoyang. It was first seen in treatise on febrile and miscellaneous diseases.

• Prevention and treatment of stroke by integrated traditional Chinese and Western medicine

Stroke, also known as "stroke" and "cerebrovascular accident", is an acute cerebrovascular disease. It is a group of diseases that cause brain tissue damage due to sudden rupture of cerebral vessels or inability of blood to flow into the brain due to vascular obstruction, including ischemic stroke and hemorrhagic stroke. Occlusion and stenosis of internal carotid artery and vertebral artery can cause ischemic stroke. The mortality of hemorrhagic stroke is high. According to the relevant surveys, the total number of strokes in urban and rural areas has become the first cause of death in China and the primary cause of disability in Chinese adults. Stroke has the characteristics of high incidence rate, high mortality rate and high disability rate. Combination of Chinese and Western medicine has unique advantages in the prevention and treatment of stroke. We apply the holistic view of “theory that man is an integral part of nature”, “ Three Categories of Etiological Factors System”, and “preventive treatment of disease” in Chinese medicine in the prevention and treatment of stroke. Through the organic combination of clinical research and basic research, the goal is to further reduce the disability rate and economic burden of society and families.