中西医结合学院

School of Integrative Medicine.

柯尊记 研究员

发布者：中西医发布时间：2021-01-14浏览次数：517

柯尊记博士

研究员

上海中医药大学中西医结合研究院，

上海市蔡伦路1200号，科技创新楼A420，

邮编：201203

电话：021-51323171（办公室）

电邮：kezunji@shutcm.edu.cn


1．研究兴趣：

主要研究兴趣：

  1. 中西医结合防治神经退行性疾病。在传统中药中寻找可以延缓老年性神经退行性疾病发展的生物活性小分子和中药复方。为防治老年性神经退行性疾病，尤其是阿尔茨海默病提供策略和方法。

  2. 阐明老年性神经元死亡的可能细胞、分子生物学机制，寻找能客观反映老龄健康的生物学标记，和延缓老年性神经元死亡的分子靶点。

  3. 探讨酒精滥用等环境因素对神经系统发育和衰老影响的细胞、分子生物学机制。


2．荣誉情况：

2014年，广西“八桂学者”讲座教授。

2009年，湖北省“楚天学者计划”讲座教授。

2006年，上海市“浦江人才计划”。

2004年，获中科院“百人计划”入选者，择优支持。


5．主要学术任职：

《医用化学与生物化学（第3版）》主编（人民卫生出版社）

《医用化学与生物化学（第2版）》主编（人民卫生出版社）

Biochemistry and Cell Biology 编委

《生命的化学》编委

《解剖学杂志》编委

中国实验动物学会神经科学技术专业委员会副主任委员

中国老年学学会衰老与抗衰老科学委员会委员

中国老年医学学会基础与转化医学分会委员

中国细胞生物学学会神经细胞生物学分会委员

中国生理学会消化与营养专委会委员

上海市中西医结合学会理事

上海市生物化学与分子生物学会理事

上海市神经科学学会理事

上海市解剖科学学会理事

上海市中医药学会亚健康分会委员

国际神经化学学会会员

美国神经科学学会会员

中国生物化学与分子生物学会科学学会会员

中国神经科学学会会员

中国营养科学学会会员

国家自然科学基金委评审人

中组部“千人计划”青年人才评审人

教育部“长江学者奖励计划”青年学者评审人


6. 科研项目：

  1. 上海市高校高峰高原学科建设项目顶尖优势团队。中医药促进老龄健康与老年性疾病防治。项目执行时间：2017.1-2021.12。正在按计划进行。

  2. 上海中医药大学中西医结合重点学科建设项目。中西医结合防治阿尔茨海默病。项目执行时间：2014.1-2018.12。已完成。

  3. 国家自然科学基金面上项目。批准号：31271142，脑内NG2细胞清除β-淀粉样蛋白的能力及其代谢途径。项目执行时间：2013.1-2016.12。获资助金额：80万元。已完成。

  4. 科技部科技部重大科学研究计划。批准号：2010CB912000；神经元信息感觉重要蛋白质膜转运的结构基础、调控及功能研究。项目执行时间：2010.1

  5. 2014.12。获资助金额：270万元。已完成。

  6. 国家自然科学基金国际会议项目。批准号：81181220504，中加老年性痴呆研讨会。项目执行时间：2011.10-2011.10。获资助金额：1.5万元。已完成。

  7. 国家自然科学基金面上项目。批准号：30870812，青春期酒精综合征的动物模型-酒精中毒性脑损伤的分子机制研究。项目执行时间：2009.1-2011.12。获资助金额：42 万元。已完成。

  8. 科技部科技部重大科学研究计划项目。批准号：2007CB947100；神经系统发育的分子调控研究。执行时间：2007.1-2011.12。获资助金额：90万元。已完成。

  9. 主持中国科学院“百人计划”。项目执行时间：2005.1-2008.12。获资助金额：200万元。已完成。

  10. 主持上海市“浦江人才计划”。项目执行时间：2006.9-2008.8。获资助金额：20万元。已完成。

  11. 主持国家自然科学基金面上项目。批准号：30570580，名称：代谢性氧化损伤，内质网应激与老年性神经元死亡。项目执行时间：2006.1-2008.12。获资助金额：26万元。已完成。

  12. 主持国家自然科学基金面上项目。批准号：30471452，名称：代谢性氧化损伤与脑内淀粉样蛋白产生。项目执行时间：2005.1-2007.12。获资助金额：20万元。已完成。

  13. 主持教育部留学回国人员科研启动基金。批准号：教外司留[2005]383号，名称：维生素B1缺乏所致的代谢性氧化损伤与脑内淀粉样蛋白产生。获资助金额：2万元。项目执行时间：2005.1-2005.12。已完成。

  14. 参与中国科学院知识创新工程重要方向项目。名称：食源小分子化合物对神经元和胰岛β－细胞分泌功能的影响及其作用的分子基础。获资助金额：30万元。项目执行时间：2007.9-2010.12。获资助金额：50万元。已完成。

  15. 参与上海市基础研究重大项目。名称：老年性痴呆症的防治与营养干预。获资助金额：20万元。项目执行时间：2007.9-2009.8。已完成。

  16. 参与上海市基础研究重大项目。名称：糖尿病性脑损伤的分子、细胞机制与营养干预。获资助金额：20万元。项目执行时间：2005.9-2007.8。已完成。


7．研究论文（*通信作者）：

  1. Su Z, Ren N, Ling Z, Sheng L, Zhou S, Guo C, Ke ZJ, Xu T, Qin Z. Differential expression of microRNAs associated with neurodegenerative diseases and diabetic nephropathy in protein l-isoaspartyl methyltransferase-deficient mice. Cell Biol Int. 2021 Nov;45(11):2316-2330.

  2. Cao Y, Li Q, Yang Y, Ke ZJ, Chen S, Li M, Fan W, Wu H, Yuan J, Wang Z, Wu X. Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway. Front Cardiovasc Med. 2021 Sep 16;8:694219.

  3. Wan Q, Kong D, Liu Q, Guo S, Wang C, Zhao Y, Ke ZJ*, Yu Y. Congestive heart failure in COX2 deficient rats. Sci China Life Sci. 2021 Jul;64(7):1068-1076.

  4. Dou B, Li S, Wei L, Wang L, Zhu S, Wang Z, Ke ZJ, Chen K, Wang Z. Astragaloside IV suppresses post-ischemic natural killer cell infiltration and activation in the brain: involvement of histone deacetylase inhibition. Front Med. 2021 Feb;15(1):79-90.

  5. Song D, Wang D, Yang Q, Yan T, Wang Z, Yan Y, Zhao J, Xie Z, Liu Y, Ke ZJ, Qazi TJ, Li Y, Wu Y, Shi Q, Lang Y, Zhang H, Huang T, Wang C, Quan Z, Qing H. The lateralization of left hippocampal CA3 during the retrieval of spatial working memory. Nat Commun. 2020 Jun 9;11(1):2901.

  6. Li M, Li SC, Dou B, Zou YX, Han HZ, Liu DX, Ke ZJ, Wang ZF. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020 Aug;41(8):1025-1032.

  7. Yan C, Liu J, Gao J, Sun Y, Zhang L, Song H, Xue L, Zhan L, Gao G, Ke ZJ, Liu Y, Liu J. IRE1 promotes neurodegeneration through autophagy-dependent neuron death in the Drosophila model of Parkinson's disease. Cell Death Dis. 2019 Oct 22;10(11):800. 

  8. Ji Z, Yuan L, Lu X, Ding H, Luo J, Ke ZJ*. Binge Alcohol Exposure Causes Neurobehavioral Deficits and GSK3β Activation in the Hippocampus of Adolescent Rats. Sci Rep. 2018 Feb 15;8(1):3088.

  9. Dou B, Zhou W, Li S, Wang L, Wu X, Li Y, Guan H, Wang C, Zhu S, Ke ZJ, Huang C, Wang Z. Buyang Huanwu Decoction Attenuates Infiltration of Natural Killer Cells and Protects Against Ischemic Brain Injury. Cell Physiol Biochem. 2018;50(4):1286-1300.

  10. Wang X, Zhang K, Yang F, Ren Z, Xu M, Frank JA, Ke ZJ, Luo J. Minocycline protects developing brain against ethanol-induced damage. Neuropharmacology. 2018 Feb;129:84-99.

  11. Wang CW, Nan DD, Wang XM, Ke ZJ, Chen GJ, Zhou JN. A peptide-based near-infrared fluorescence probe for dynamic monitoring senile plaques in Alzheimer’s disease mouse model. Sci Bull (Beijing). 2017 Dec 15;62(23):1593-1601

  12. Ren Z, Wang X, Yang F, Xu M, Frank JA, Wang H, Wang S, Ke ZJ, Luo J. Ethanol-induced damage to the developing spinal cord: The involvement of CCR2 signaling. Biochim Biophys Acta. 2017 Nov;1863(11):2746-2761.

  13. Yang Z, Lv J, Li X, Meng Q, Yang Q, Ma W, Li Y, Ke ZJ*. Sevoflurane decreases self-renewal capacity and causes c-Jun N-terminal kinase-mediated damage of rat fetal neural stem cells. Sci Rep. 2017 Apr 10;7:46304.

  14. Wang X, Xu M, Frank JA, Ke ZJ, Luo J. Thiamine deficiency induces endoplasmic reticulum stress and oxidative stress in human neurons derived from induced pluripotent stem cells. Toxicol Appl Pharmacol. 2017 Apr 1;320:26-31

  15. Ren Z, Yang F, Wang X, Wang Y, Xu M, Frank JA, Ke ZJ, Zhang Z, Shi X, Luo J. Chronic plus binge ethanol exposure causes more severe pancreatic injury and inflammation. Toxicol Appl Pharmacol. 2016 Oct 1;508:11-19.

  16. Ren Z, Wang X, Xu M, Yang F, Frank JA, Ke ZJ, Luo J. Binge ethanol exposure causes endoplasmic reticulum stress, oxidative stress and tissue injury in the pancreas. Oncotarget. 2016 Aug 5;7(34):54303-316.

  17. Xu M, Ren Z, Wang X, Comer A, Frank JA, Ke ZJ, Huang Y, Zhang Z, Shi X, Wang S, Luo J. ErbB2 and p38γ MAPK mediate alcohol-induced increase in breast cancer stem cells and metastasis. Mol Cancer. 2016 Jul 14;15(1):52.

  18. Xu DQ, Wang Z, Wang CY, Zhang DY, Wan HD, Zhao ZL, Gu J, Zhang YX, Li ZG, Man KY, Pan Y, Wang ZF, Ke ZJ, Liu ZX, Liao LJ, Chen Y. PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity.The EMBO Journal (2016) 35: 496–514.

  19. Xu M, Wang S, Ren Z, Frank JA, Yang XH, Zhang Z, Ke ZJ, Shi X, Luo J. Chronic ethanol exposure enhances the aggressiveness of breast cancer: the role of p38γ. Oncotarget. 2016 Jan 19;7(3):3489-505.

  20. Wang H, Wang X, Ke ZJ, Comer AL, Xu M, Frank JA, Zhang Z, Shi X, Luo J. Tunicamycin-induced unfolded protein response in the developing mouse brain. Toxicol Appl Pharmacol. 2015 Mar 15;283(3):157-67.

  21. Yong Y, Meng Y, Ding H, Fan Z, Tang Y, Zhou C, Luo J, Ke ZJ*. PACT/RAX Regulates the Migration of Cerebellar Granule Neurons in the Developing Cerebellum. Sci Rep. 2015 Jan 22;5:7961.

  22. Ji Z, Fan Z, Zhang Y, Yu R, Yang H, Zhou C, Luo J, Ke ZJ*. Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: The Involvement of CCL2. J Immunol. 2014 Sep 1;193(5):2157-67.

  23. Yao J, Ke ZJ, Wang X, Peng F, Li B, Wu R. Epithelial-mesenchymal transition and apoptosis of renal tubular epithelial cells are associated with disease progression in patients with IgA nephropathy. Mol Med Rep. 2014 Jul;10(1):39-44.

  24. Liu M, Alimov AP, Wang H, Frank JA, Katz W, Xu M, Ke ZJ, Luo J. Thiamine deficiency induces anorexia by inhibiting hypothalamic AMPK. Neuroscience. 2014 Mar 5;267:102-113

  25. Wang F, Chen H, Sun XJ, Ke ZJ*. Improvement of cognitive deficits in SAMP8 mice by 3-n-butylphthalide. Neurol Res. 2014 Mar;36(3):224-33.

  26. Liu L, Fan Z, Tang Y, Ke ZJ. The Resveratrol Attenuates Ethanol-Induced Hepatocyte Apoptosis Via Inhibiting ER-Related Caspase-12 Activation and PDE Activity In Vitro. Alcohol Clin Exp Res. 2014 Mar;38(3):683-93.

  27. Wang H, Ke ZJ, Alimov A, Xu M, Frank JA, Fang S, Luo J. Spatiotemporal Expression of MANF in the Developing Rat Brain. PLoS One. 2014 Feb 28;9(2):e90433.

  28. Meng Y, Yong Y, Yang G, Ding H, Fan Z, Tang Y, Luo J, Ke ZJ*. Autophagy alleviates neurodegeneration caused by mild impairment of oxidative metabolism. J Neurochem. 2013 Sep;126(6):805-18.

  29. Li W, Tang Y, Fan Z, Meng Y, Yang G, Luo J, Ke ZJ*. Autophagy is involved in oligodendroglial precursor-mediated clearance of amyloid peptide. Mol. Neurodegener. 2013 Aug 10;8:27.

  30. Zhang G, Ding H, Chen H, Ye X, Li H, Lin X, Ke ZJ*. Thiamine Nutritional Status and Depressive Symptoms Are Inversely Associated among Older Chinese Adults. J Nutr. 2013 Jan;143(1):53-8.

  31. Chen G, Ke ZJ, Xu M, Liao M, Wang X, Qi Y, Zhang T, Frank JA, Bower KA, Shi X, Luo J. Autophagy is a protective response to ethanol neurotoxicity. Autophagy. 2012 Nov;8(11):1577-89

  32. Wang X, Ke ZJ, Chen G, Xu M, Bower KA, Frank JA, Zhang Z, Shi X, Luo J. Cdc42-dependent activation of NADPH oxidase is involved in ethanol-induced neuronal oxidative stress. PLoS One. 2012;7(5):e38075.

  33. Wang X, Mandal AK, Saito H, Pulliam JF, Lee EY, Ke ZJ, Lu J, Ding S, Li L, Shelton BJ, Tucker T, Evers BM, Zhang Z, Shi X. Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway. Toxicol Appl Pharmacol. 2012 Jul 1;262(1):11-21

  34. Wang S, Xu M, Li F, Wang X, Bower KA, Frank JA, Lu Y, Chen G, Zhang Z, Ke Z, Shi X, Luo J. Ethanol promotes mammary tumor growth and angiogenesis: the involvement of chemoattractant factor MCP-1. Breast Cancer Res Treat. 2012 Jun;133(3):1037-48

  35. Ji Z,Ke ZJ, Geng JG. SAP suppresses the development of experimental autoimmune encephalomyelitis in C57BL/6 mice.Immunol Cell Biol. 2012 Apr;90(4):388-95.

  36. Sun X, Xiong Z, Zhang Y, Meng Y, Xu G, Xia Z, Li J, Zhang R, Ke Z, Xia Z, Hu Y. Harpagoside attenuates MPTP/MPP(+) induced dopaminergic neurodegeneration and movement disorder via elevating glial cell line-derived neurotrophic factor. J Neurochem. 2012 Mar;120(6):1072-83

  37. Wang X, Son YO, Chang Q, Sun L, Hitron JA, Budhraja A, Zhang Z, Ke Z, Chen F, Luo J, Shi X. NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium. Toxicol Sci. 2011 Oct;123(2):399-410.

  38. Ke ZJ, Wang X, Liu Y, Fan Z, Chen G, Xu M, Bower KA, Fank JA, Li M, Fang S, Shi X, Luo J. Ethanol Induces Endoplasmic Reticulum Stress in the Developing Brain. Alcohol Clin Exp Res. 2011;35(9): 1574–1583.

  39. Ke ZJ, Liu Y, Wang X, Fan Z, Chen G, Xu M, Bower KA, Frank JA, Ou X, Shi X, Luo J. Cyanidin-3-glucoside ameliorates ethanol neurotoxicity in the developing brain. J Neurosci Res. 2011 Oct;89(10):1676-84.

  40. Zhang Z, Li W, Cheng S, Yao H, Zhang F, Chang Q, Ke ZJ, Wang X, Son YO, Luo J, Shi X. Nickel-induced Down-regulation of ΔNp63 and its Role in The Proliferation of Keratinocytes. Toxicol Appl Pharmacol. 2011 Jun 15;253(3):235-43.

  41. Yang G, Meng Y, Li W, Yong Y, Fan Z, Ding HQ, Wei YZ, Luo J,Ke ZJ*. Neuronal MCP-1 Mediates Microglia Recruitment and Neurodegeneration Induced by the Mild Impairment of Oxidative Metabolism. Brain Pathol. 2011;21(3):279-297

  42. Yong Y, Ding H, Fan Z, Luo J, Ke ZJ*. Lithium Fails to Protect Dopaminergic Neurons in the 6-OHDA Model of Parkinson's Disease. Neurochem Res. 2011, 36(3):367-74.

  43. Tu ML, Wang HQ, Sun XD, Chen LJ, Peng XC, Yuan YH, Li RM, Ruan XZ, Li DS, Xu YJ, Ke ZJ. Pim-1 is up-regulated by shear stress and is involved in shear stress-induced proliferation of rat mesenchymal stem cells. Life Sci. 2011, 88(5-6):233-8.

  44. Zhang QP, Yang G, Li WX, Fan Z, Sun AY, Luo J,Ke ZJ*. Thiamine deficiency increases -secretase activity and accumulation of β-amyloid peptides. Neurobiol. Aging. 2011;32(1):42-53.

  45. Cheng S, Gao N, Zhang Z, Chen G, Budhraja A, Ke ZJ, Son YO, Wang X, Luo J, Shi X. Quercetin induces tumor-selective apoptosis through down-regulation of Mcl-1 and activation of Bax. Clin Cancer Res, 2010 Dec 1;16(23):5679-91.

  46. Lee SC, Yang G, Liu Y, Zhao L, Xu J, Zhang X, Wan Y, Feng C, Fan ZQ, Liu Y, Luo J, Ke ZJ*. ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics. Mol Neurodeger. 2010,5:54 (27 November 2010)

  47. Xu M, Bower KA, Wang S, Frank JA, Chen G, Ding M, Wang S, Shi X, Ke ZJ, Luo J. Cyanidin-3-Glucoside Inhibits Ethanol-induced Invasion of Breast Cancer Cells Overexpressing ErbB2. Mol Cancer 2010 Oct 29;9:285.

  48. Wang X, Meng D, Chang Q, Pan J, Zhang Z, Chen G,Ke ZJ, Luo J, Shi X. Arsenic Inhibits Neurite Outgrowth by Inhibiting LKB1-AMPK Signaling Pathway. Environ Health Perspect. 2010;118(5):627-34.

  49. Xu M, Bower KA, Chen G, Shi X, Dong Z, Ke ZJ, Luo J. Ethanol Enhances the Interaction of Breast Cancer Cells Over-Expressing ErbB2 with Fibronectin. Alcohol Clin Exp Res. 2010;34(5):751-60.

  50. Xu G, Xiong Z, Yong Y, Wang Z, Ke ZJ, Xia Z, Hu Y. Catalpol attenuates MPTP induced neuronal degeneration of nigral-striatal dopaminergic pathway in mice through elevating glial cell derived neurotrophic factor in striatum. Neuroscience. 2010;167(1):174-84.

  51. You J, Yu Y, Jiang L, Li W, Yu X, Gonzalez L, Yang G,Ke ZJ, Li W, Li C, Liu Y. Signaling through Tyr985 of Leptin Receptor as an Age/diet-dependent Switch in the Regulation of Energy Balance. Mol Cell Biol. 2010;30(7):1650-9.

  52. Ke ZJ, Wang X, Fan Z, Luo J. Ethanol promotes thiamine deficiency-induced neuronal death: involvement of double-stranded RNA-activated protein kinase. Alcohol Clin Exp Res. 2009;33(6):1097-103.

  53. Chen G, Bower KA, Xu M, Ding M, Shi X, Ke ZJ, Luo J. Cyanidin-3-glucoside reverses ethanol-induced inhibition of neurite outgrowth: role of glycogen synthase kinase 3 Beta.Neurotox Res. 2009 May;15(4):321-31.

  54. Liu Y., Chen, G., Ma, C., Bower, KA.,Xu, M., Fan, Z., Shi, X., Ke, ZJ and Luo, J. Over-expression of GSK3beta sensitizes neuronal cells to ethanol toxicity. J. Neurosci Res. 2009, 87:2793-2802.

  55. Zhang Q, Ding H, Li W, Fan Z, Sun A, Luo J, Ke ZJ*. Senescence accelerated mouse strain is sensitive to neurodegeneration induced by mild impairment of oxidative metabolism. Brain Res. 2009 Apr 6;1264:111-8.

  56. Chen YY, Chen G, Fan ZQ, Luo J, Ke ZJ*. GSK3β and Endoplasmic Reticulum Stress Mediate Rotenone-induced Death of SK-N-MC Neuroblastoma Cells. Biochem. Pharmacol. 2008; 76(1):128-38.

  57. Ma C, Bower KA, Chen G, Shi X, Ke ZJ, Luo J. Interaction between ERK and GSK 3beta mediates basic FGF-induced apoptosis in SK-N-MC neuroblastoma cells. J Biol Chem.2008; 283(14):9248-56.

  58. Chen G, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Ethanol promotes endoplasmic reticulum stress-induced neuronal death: Involvement of oxidative stress. J Neurosci Res. 2008; 86(4):937-46.

  59. Wang X, Fan ZQ, Wang B, Luo J, Ke ZJ*. Activation of PKR by mild impairment of oxidative metabolism in neurons. J Neurochem. 2007, 103 (6): 2380–2390.

  60. Ma C, Wang J, Gao Y, Gao TW, Chen G, Bower KA, Odetallah M, Ding M, Ke ZJ, Luo J. The Role of Glycogen Synthase Kinase 3 beta in the Transformation of Epidermal Cells. Cancer Res. 2007, 67(16):7756-64.

  61. Cai G, Wang J, Xin X, Ke ZJ, Luo J. Phosphorylation of Glycogen Synthase Kinase-3 beta at Serine 9 Confers Cisplatin Resistance in Ovarian Cancer Cells. Int J Oncol. 2007, 31(3)657-62.

  62. Chen G, Fan ZQ, Wang X, Ma C, Bower KA, Shi X, Ke ZJ, Luo J. Brain-derived Neurotrophic Factor Suppresses Tunicamycin-induced Upregulation of CHOP in Neurons. J Neurosci Res. 2007, 85(8):1674-1684.

  63. Wang X, Wang BW, Fan ZQ,Shi XL, Ke ZJ*, and Luo J. Thiamine Deficiency Induces Endoplasmic Reticulum Stress in Neurons. Neurosciences. 2007, 144(3):1045-56.

  64. Chen G, Ma C, Bower KA, Ke ZJ, and Luo J. Interaction between Rax and PKR modulates the effect of ethanol on protein synthesis and survival of neurons. J Biol Chem, 2006, 281(23):15909-15915.

  65. Ke ZJ, Bowen WM, Gibson GE. Peripheral inflammatory mechanisms modulate microglial activation in response to mild impairment of oxidative metabolism. Neurochem Int. 2006, 49(5): 548-556.

  66. Ke ZJ, Lin H, Fan ZQ, Cai TQ, Kaplan RA, Ma C, Bower KA, Shi X, and Luo J. MMP-2 Partially Mediates Ethanol-induced Invasion of Mammary Epithelial Cells Over-expressing ErbB2. Intl J Cancer, 2006, 119(1): 8-16.

  67. Ke ZJ, Calingasan NY, Karuppagounder SS, Degiorgio LA, Volpe BT, Gibson GE.CD40L Deletion Delays Neuronal Death in a Model of Neurodegeneration Due to Mild Impairment of Oxidative Metabolism. J Neuroimmunol. 2005, 164(1-2):85-92.

  68. Ke ZJ, Calingasan NY, Volpe BT, Gibson GE. CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolism. Neurochem Int. 2005, 47(3): 204-215.

  69. Bubber P, Ke ZJ and Gibson GE. Tricarboxylic acid cycle enzymes following thiamine deficiency. Neurochem Int. 2004, 45(7):1021-8.

  70. Ke ZJ, DeGiorgio LA, Volpe BT, Gibson GE. Reversal of thiamine deficiency-induced neurodegeneration. J Neuropath Exp Neurol. 2003; 62 (2): 195-207.

  71. Carlstrom L*, Ke ZJ* (equal contribution), Unnerstall JR, Cohen RS and Pandey SC. Estrogen Modulation of the Cyclic AMP Response Element-binding Protein (CREB) Pathway: Effects of Long-term and Acute Treatments. Neuroendocrinology, 2001; 74:227-243.

  72. Wang HY, Zhang FC, Gao JJ, Fan JB, Liu P, Zheng ZJ, Xi H, Sun Y, Gao XC, Huang TZ, Ke ZJ, Guo GR, Feng GY, Breen G, Clair DS, He L. Apolipoprotein E is a genetic risk factor for fetal iodine deficiency disorder in China. Mol Psychiatry 2000; 5(4): 363-8

  73. 柯尊记, 姚志彬。老年大鼠学习记忆减退与海马GABA 阳性树突内线粒体的变化。神经解剖学杂志。1999; 15(2): 192-195。

  74. 柯尊记, 姚志彬，陈以慈。年龄相关的空间参考记忆和空间工作记忆能力减退。中国行为医学科学杂志。1999; 8(4): 245-248。

  75. 柯尊记,刘志敏，姜德鸣，戚正武。脑内转移脑源性神经营养因子基因促进穹窿切断大鼠神经纤维抽芽及功能恢复。中国神经科学杂志。1998; 14(3): 127-133。

  76. 柯尊记,王亚威，周兰仙，胡家荦。大鼠乳头体核突触的生后发育－－亚突触结构的定量研究。神经解剖学杂志。1992; 8:211-216.

  77. 张颖，柯尊记，杨坚，贾新玲，张欣。芍药甘草汤及其活性成分的脑保护作用机制研究概述。现代生物医学进展。2014;14(34):6773-7

  78. 余荣环，黄莺，胡斌，黄运平，王琼，茅俊杰，管超，杨海华，柯尊记。COPD患者维生素B1的营养状况及其相关预后分析。临床肺科杂志。2014;19(9):1569-71

  79. 张颖,杨坚,刘罡一,贾新玲,严国锋,刘海明,吴绮,柯尊记*. 芍药甘草汤对脑缺血再灌注偏瘫大鼠痉挛状态和氨基酸水平的影响. 上海中医药杂志2015/0549(544):85-89

  80. 胡斌，黄运平，茅俊杰，管超，余荣环，杨海华，柯尊记。维生素B1缺乏与老年慢性阻塞性肺疾病相关性研究。老年医学与保健。2015, 21(1)：46-49。

  81. 陈龙菊,吴建清,吴太鼎,陈传奇,谭云霞,柯尊记.葛根素保护双氧水诱导的SH-SY5Y细胞凋亡[J].中国药理学通报,2018,34(03):343-347.

  82. 陈龙菊, 陈传奇, 谭云霞,吴太鼎，柯尊记. 葛根素对臂丛撕脱后脊髓运动神经元GAP-43及NGF蛋白表达的影响 [J].中华显微外科杂志,2018,41( 1 ): 62-65.

  83. 高玮,李春霞,柯尊记,刘芳,秦瑜,陆骏.鼓槌石斛乙醇提取物对糖尿病大鼠视网膜组织凋亡相关因子表达的影响[J].上海中医药大学学报,2018,32(04):89-94.

  84. 丁涵青,张颖,韦璐瑶,李紫,柯尊记.精氨酸及其代谢产物对缺血性脑卒中的作用[J].现代生物医学进展,2021,21(11):2179-2183.


8．综述（*通信作者）：

  1. 张媛爽,李清华,柯尊记.前列腺素E2与缺血性脑卒中[J].生命的化学,2021,41(04):625-632.

  2. 郭珂一，李清华，柯尊记． 黄芪散对阿尔茨海默病的防治作用研究进展． 新乡医学院学报，2020，37(5):489-493．

  3. 杨桂珍，柯尊记.抗炎中药与阿尔茨海默病防治. 世界科学技术-中医药现代化. 2019，9：1917-1923。

  4. 王志恒,李清华,柯尊记.肌醇1,4,5-三磷酸受体与阿尔茨海默病[J].生命科学,2019,31(07):660-664.

  5. 高宇宏,柯尊记.肉苁蓉治疗阿尔茨海默病药理作用研究进展[J].上海中医药杂志,2018,52(01):109-112.

  6. 安竹燕，李清华，柯尊记*. 维生素B3与帕金森病的防治[J/OL]. 生命科学。 2017, 29(8): 773-778

  7. Liu D, Ke ZJ, Luo J. Thiamine Deficiency and Neurodegeneration: the Interplay Among Oxidative Stress, Endoplasmic Reticulum Stress, and Autophagy. Mol Neurobiol. 2017 Sep;54(7):5440-5448.

  8. Wang Y, Xu M, Ke ZJ, Luo J. Cellular and molecular mechanisms underlying alcohol-induced aggressiveness of breast cancer. Pharmacol Res. 2017 Jan;115:299-308.

  9. Klionsky DJ,… , Ke ZJ,…, Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).Autophagy. 2016 Jan 2;12(1):1-222.

  10. Ke ZJ*, Luo J. Response to Comment on "Thiamine Deficiency Promotes T Cell Infiltration in Experimental Autoimmune Encephalomyelitis: The Involvement of CCL2". J Immunol. 2014 Nov 15;193(10):4755-6.

  11. Yong Y, Luo J, Ke ZJ*. dsRNA-binding protein PACT/RAX in Gene Silencing, Development and Diseases. Front Biol (Beijing). 2014, 9 (5): 382-388.

  12. 李文霞，柯尊记*。维生素B1缺乏与老年性痴呆。生命科学。2013; 25(2):56-62.

  13. Chen Y, Lin X, Liu Y, Xie D, Fang J, Le Y, Ke Z, Zhai Q, Wang H, Guo F, Wang F, Liu Y. Research advances at the institute for nutritional sciences at shanghai, china. Adv. Nutr. 2011 Sep;2(5):428-39.

  14. 刘丽琼，骆嘉, 柯尊记*。细胞因子与酒精性肝病。生命科学。2010; 22(12):1241-6。

  15. 刘莹, 骆嘉, 柯尊记*。酒精诱导突触发生期神经元凋亡的分子机理。生命科学。2008; 20(1):111-115。

  16. Ke ZJ, and Gibson GE. Selective Response of Various Brain Cell Types DuringNeurodegeneration Due to Mild Impairment of Oxidative Metabolism. Neurochem Int. 2004, 45 (2-3): 361-369.

  17. 柯尊记,　姚志彬。老年学习记忆减退大鼠的海马GABA能神经元数量变化。解剖科学进展2000；6（2）：148-151。

  18. 柯尊记, 姚志彬，陈以慈。空间学习记忆的分子神经生物学机制。解剖科学进展。1998, 4(1): 1-7.

  19. 柯尊记, 姚志彬。中枢神经系统疾病的基因治疗。解剖学通报。1997;19(2): 47-52.

  20. 柯尊记, 陈以慈，姚志彬。老年学习记忆减退的神经行为学基础。生理科学进展。1997; 28(4): 328-330.


9．主编与专著章节：

  1. 柯尊记 主编。《医用化学与生物化学（第3版）》。2021年07月，ISBN：9787117316538，人民卫生出版社。

  2. 柯尊记 主编。《医用化学与生物化学（第2版）》。2016年09月，ISBN：9787117225649，人民卫生出版社。

  3. 孟雅，柯尊记。亚临床维生素B1缺乏与老年性神经退行性疾病。马永兴，俞卓伟, 主编。《衰老、痴呆与预防医学新进展》 2013. ISBN 978-7-5023-8024-3科学技术文献出版社

  4. Ke ZJ and Luo J. Thiamine Deficiency and Neuronal Calcium Homeostasis. In Food and Nutritional Components in Focus No. 4. B Vitamins and Folate: Chemistry, Analysis, Function and Effects. Edited by Victor R. Preedy, The Royal Society of Chemistry 2013。ISBN: 978-1-84973-369-4


10.专利：

  1. 柯尊记，黄诚，张颖，贾新玲，丁涵青，袁琳，骆嘉。黄芪散在制备预防或治疗阿尔茨海默病的药物中的应用。上海中医药大学。申请号：ZL201611179930.3。授权日期: 2019.11.16。

  2. 柯尊记,骆嘉,李文霞,唐义芬,范志勤。清除淀粉样多肽的细胞及其应用。中国科学院上海生命科学研究院。 ZL 201310079159.2。授权日期: 2016.3.16。

  3. 柯尊记, 骆嘉, 范志勤, 杨光: 防治神经退行性疾病的试剂和方法. 中国科学院上海生命科学研究院。 ZL 201010250174.5。授权日期: 2014.7.16。

  4. 李 巍,乔海晅,李 岩,柯尊记,许执恒。xCT蛋白及其编码基因的新用途。中国科学院遗传与发育生物学研究所。申请（专利）号：CN200610089373.6。申请日期：2006年6月22日。公开(公告)日：2006年12月27日。公开(公告)号：CN1883700。