中西医结合学院

School of Integrative Medicine.

徐见容 副研究员

发布者：中西医发布时间：2020-11-24浏览次数：1026


徐见容，副研究员，硕士生导师

电子邮箱：

办公室电话：(021) 5132-3186

通讯地址：浦东新区蔡伦路1200号创新科技楼4楼A410


Jianrong (Janker) Xu, Associate research fellow, Master Supervisor

Email: janker.xu@gmail.com

TEL: (021) 5132-3186

Contact address: A410, 4/F, Innovation and Technology Building, 1200 Cailun Rd, Pudong, Shanghai



学习和研究经历

  • 2020.09-至今,  副研究员，上海中医药大学，中西医结合研究院

  • 2018.04-2020.08，博士后，澳大利亚莫纳什大学，莫纳什药物研究所

  • 2016.02-2018.04，讲师，上海交通大学医学院，药理学与化学生物学系

  • 2013.11-2016.01，博士后，上海交通大学医学院，药理系

  • 2010.09-2013.10，博士研究生，上海交通大学医学院，药理系

  • 2009.07-2010.08，分析研究员，药明康德新药开发有限公司，核心分析部

  • 2007.09-2009.06，硕士研究生，武汉大学，药学院

  • 2003.09-2007.06，本科，武汉大学，药学院

Education and Research Experience

  • 2020.09-Present,  Associate Research Fellow, Academy of Integrative Medicine, Shanghai University of Traditional Chinese Medicine

  • 2018.04-2020.08, Post Doctoral, Monash Institute of Pharmaceutical Science, Monash University

  • 2016.02-2018.04, Lecturer, Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine

  • 2013.11-2016.01, Post Doctoral, Department of Pharmacology, Shanghai Jiao Tong University School of Medicine

  • 2010.09-2013.10, Ph.D. program, Department of Pharmacology, Shanghai Jiao Tong University School of Medicine

  • 2009.07-2010.08, Analytical Scientist, CAS, Wuxi Apptec

  • 2007.09-2009.06, M.S. program, College of Pharmaceutical Science, Wuhan University

  • 2003.09-2007.06, B.S. program, College of Pharmaceutical Science, Wuhan University



研究领域（Research area）

  • 神经退行性疾病关键靶标的调控机制研究

  • 基于表面等离子共振分析（SPR）的中药靶标发现及机制研究

  • 多靶点抗阿尔茨海默病新药研究

Research area

  • Modulation of targets against neurodegenerative diseases

  • SPR-based target identification and mechanism of action for TCM

  • Discovery of novel multipotent anti-Alzheimer drugs



研究成果

研究领域主要聚焦阿尔茨海默病等重大神经退行性疾病的重要靶标（如M1胆碱受体、β淀粉样多肽等），综合应用药物-靶标互作分析（SPR技术）、受体功能表征、计算机模拟等多种交叉学科方法，开展天然活性分子的药理作用机制和规律的研究，为靶标调控新途径提供理论依据，并发掘候选新药。目前已在Cell Research、Nature Chemical Biology、Nano Research、FASEB J等杂志发表SCI论文50余篇（总IF=278；6篇IF>10；20篇IF>5；h-index=12），其中第一/通讯作者（含共同）论文9篇（均IF>4），申请/授权专利9项，获教育部科技进步一等奖1项，上海市科技进步一等奖1项，中华医学科技二等奖1项。

Achievements

He has focused on critical targets of important neurodegenerative diseases such as Alzheimer’s Disease (e.g. M1 muscarinic acetylcholine receptor and β-amyloid peptide). By employing interdisciplinary technologies, such as drug-target interaction analysis methodology (e.g. SPR analysis), receptor function characterization and in-silico modelling, he devoted himself to elucidating pharmacological mechanisms for natural bioactive molecules, providing evidence for novel ideas of target modulation and developing drug candidates.

He has published more than 50 papers in SCI journals, such as Cell Research、Nature Chemical Biology、Nano Research、FASEB J, with an h-index (2021) of 13. He applied for 9 patents, and four of them have been granted. Besides, the research achievements won 3 awards, including the Science and Technology Progress Award of the Ministry of Education (1st class), the Science and Technology Progress Award of Shanghai (1st class), and The Chinese Medical Science and Technology Award (2nd class).



获奖

  • 上海市科技进步一等奖（2017），阿尔茨海默病靶标新药的基础和临床研究以及早期识别/干预策略，（11/15）

  • 中华医学科技二等奖（2017），胆碱系统药理学的调控新机制以及靶标新药的研究，（10/10）

  • 教育部科技进步奖一等奖（2015），阿尔茨海默病防治药物的基础和临床药理学研究，（13/15）

  • 上海市教委新教师培训优秀学员（2016）

  • 上海交通大学医学院优秀博士后（2016）

Awards

  • The Science and Technology Progress Award of Shanghai (1st class, 2017)

  • The Chinese Medical Science and Technology Award (2nd class, 2017)

  • The Science and Technology Progress Award of the Ministry of Education (1st class, 2016 )

  • “Excellent Trainee” Awarded by Shanghai Municipal Education Commission (2016)

  • “Excellent Post-Doctoral Scholar” Awarded by Shanghai Jiao Tong University School of Medicine (2016)



专利

  1. 陈红专 , 王昊 , 徐见容, 侯丽娜 , 王宇 , 赵恒毅 , 郑兆浠 , 史玉欢。作为毒蕈碱受体M1亚型调节剂的多肽及其制备方法和用途 ，CN104910255B，中国发明专利。

  2. 权静 , 郑永利 , 徐见容, 赵兰雪。一种荧光滴定检测温敏含糖无规聚合物与凝集素相互作用的方法 ，CN111157502B，中国发明专利。

  3. 王昊 , 徐见容, 陈红专 , 胡梦薇 , 赵兰雪 , 侯丽娜 , 王宇 , 李苗苗 , 黄婉莹。一种基于抗体的乙酰胆碱酯酶芯片固定方法及其在小分子抑制剂研发中的应用 ，CN109239153B，中国发明专利。

  4. 唐德伟 , 徐见容, 黄辰 , 李苗苗 , 吴星宇。M2乙酰胆碱受体拮抗剂及其用途，CN113527172A，中国发明专利。

  5. 王昊 , 王刚 , 任汝静 , 陈红专 , 胡勇博 , 徐见容, 张永芳 , 张瑞 , 侯丽娜 , 赵兰雪 , 黄婉莹。microRNA-425及其类似物作为阿尔茨海默病治疗的核苷酸药物的应用 ，CN111603561A，中国发明专利。

  6. 方超 , 陈红专 , 管滢芸 , 赵梅 , 栾鑫 , 陆琴 , 徐见容, 刘亚蓉 , 高云鸽 , 刘海军。竹节香附素A在制备抑制血管生成药物中的应用 ，CN104161766A，中国发明专利。

  7. 徐见容，一种降血糖和降血脂的保健食品及其生产方法 ，CN107625129A，中国发明专利。

  8. 方超 , 陈红专 , 栾鑫 , 赵梅 , 管滢芸 , 陆琴 , 徐见容, 刘亚蓉 , 刘海军 , 高云鸽。桔梗皂苷D在制备抑制血管生成药物中的应用 ，CN104161765A，中国发明专利。

  9. 肖玉秀 , 汪志明 , 徐见容, 倪峙旭。一种毛细管冲洗及进样两用器 ，CN201503412U，中国实用新型专利。

  10. 肖玉秀 , 徐见容, 倪峙旭。一种毛细管窗口制作器 ，CN201454416U，中国实用新型专利。

  11. 肖玉秀 , 徐见容。一种用于正交式激光诱导荧光检测器的四维可调毛细管夹持器 ，CN201322719Y，中国实用新型专利。

Patents

  1. Hongzhuan Chen, Hao Wang, Jianrong Xu, Lina Hou, Yu Wang, Hengyi Zhao, Zhaoxi Zheng, Yuhuan Shi. (2015): "Preparation and usage of the peptide as modulator of M1 muscarinic acetylcholine receptor" (China patent No: CN104910255B)

  2. Quan Jing, Zheng Yongli, Xu Jianrong, Zhao Lanxue. (2020): “Method for detecting interaction between temperature-sensitive sugar-containing random polymer and lectin by fluorescence titration” (China patent No: CN111157502B)

  3. Hao Wang, Jianrong Xu, Hongzhuan Chen, Mengwei Hu, Lanxue Zhao, Lina Hou, Yu Wang, Miaomiao Li, Wanying Huang. (2018): "The immobilization method for acetylcholinesterase chip based on antibodies and the application in the discovery of small molecule inhibitors" (China patent No: CN109239153B)

  4. Tang Dewei, Xu Jianrong, Huang Chen, Li Miaomiao, Wu Xingyu. (2020): " The use of M2 muscarinic acetylcholine receptor antagonists " (China patent No: CN113527172A)

  5. Hao Wang, Gang Wang, Rujing Ren, Hongzhuan Chen, Yongbo Hu, Jianrong Xu, Yongfang Zhang, Rui Zhang, Lina Hou, Lanxue Zhao, Wanying Huang. (2019): "The application of microRNA-425 and the analogues as nucleotide reagents in the therapy of Alzheimer's disease" (China patent No: CN111603561A)

  6. Chao Fang, Hongzhuan Chen, Yingyun Guan, Mei Zhao, Xin Luan, Qin Lu, Jianrong Xu, Yarong Liu, Yunge Gao, Haijun Liu. (2014): "The application of Raddeanin A in the preparation of angiogenesis inhibiting agents" (China patent No: CN104161766A)

  7. Jianrong Xu. (2017): "Health food for lowering blood sugar and blood fat and its production method" (China patent No: CN107625129A)

  8. Chao Fang, Hongzhuan Chen, Xin Luan, Mei Zhao, Yingyun Guan, Qin Lu, Jianrong Xu, Yarong Liu, Haijun Liu, Yunge Gao. (2014): "The application of Platycodin D in the preparation of angiogenesis inhibiting agents" (China patent No: CN104161765A)

  9. Yuxiu Xiao, Zhiming Wang, Jianrong Xu, Zhixu Ni. (2009): "A dual-purpose tool for capillary rinse and injection" (China patent No: CN201503412U)

  10. Yuxiu Xiao, Jianrong Xu, Zhixu Ni. (2009): "A production tool to prepare capillary window" (China patent No: CN201454416U)

  11. Yuxiu Xiao, Jianrong Xu. (2008): "A 4-D adjustable capillary holder applied in orthogonal laser-induced fluorescence detector" (China patent No: CN201322719Y)



基金支持及参与（Grant Funding）

  • 主持国家自然科学基金2项

1. 国自然面上项目：M1胆碱受体SUMO化修饰增强Gαq偶联并促进受体运输的分子动力学和认知改善效应研究（82173798），2022.01-2025.12，获55万资助，在研，主持；

2. 国自然面上基金：M1 胆碱受体激动剂对 Gαq、Gαs 及 β-arrestin 信号通路的偏向性激活及其分子机制（81503174），2016.01-2018.12，获18.2万资助，已结题，主持；

  • 参与国家自然科学基金4项

1. 国自然面上项目：α7烟碱型乙酰胆碱受体介导的中枢抗炎通路的转录后调节新机制（81973297），2020.01-2023.12，获55万资助，在研，参加；

2. 国自然面上项目：M1受体选择性激活和Gαq-PKC信号偏好的变构新位点发掘及调控机制研究（81872841），2019.01-2022.12，获60万资助，在研，参加；

3. 国自然青年项目：阿尔茨海默病中M1受体解偶联对AMPA受体介导突触可塑性与认知功能的调控机制（81803499），2019.01-2021.12，获21万资助，在研，参加；

4. 国自然面上项目：乙酰胆碱酯酶新基序AChE7-20非酶活性依赖的海马神经元毒性调控机制（81573415），2016.01-2019.12，获72万资助，已结题，参加；

5. 国自然面上项目：基于MT7生物毒素的M1受体高选择性先导物的改造及其药理活性研究（81373395），2014.01-2017.12，获65万资助，已结题，参加；

  • 2021年“中西医结合防治脑病的临床与基础研究”上海市教委专项拨款，50万元；

  • 2020年获上海中医药大学“青年杏林学者”培养计划资助，15万元；

  • 2020年承担上海强睿生物科技有限公司横向课题“抗神经退行性疾病新药开发研究”，20万元；

  • 2017年获上海市教委“优秀青年教师计划”，8万元；

  • 2017年获上海交通大学“新进青年教师启动计划”，20万元；

  • 2014年获中国博士后基金国际交流项目，3万元；

  • 2014年获中国博士后基金面上项目，5万元；


Grant Funding

  • Granted 2 National Natural Science Foundation of China (NSFC) funds as PI and other 4 NSFC projects as Co-PI

  • Shanghai Municipal Education Commission special grant for " Basic and clinical research on prevention and treatment of encephalopathy with integrated traditional Chinese and western medicine " (2021)

  • "Young Xinglin scientists" Program funded by Shanghai University of Traditional Chinese Medicine (2020)

  • "New Young Teacher Launch" Program funded by Shanghai Jiao Tong University (2017)

  • "Academic Exchange Program of International Exchange" Program funded by the China Postdoctoral Science Foundation (2015)

  • "General Financial Grant" Program funded by the China Postdoctoral Science Foundation (2014)



论文发表（Publication）

1.Zhang, Qiufen; Chen, Yingyi; Ni, Duan; Huang, Zhimin; Wei, Jiacheng; Feng, Li; Su, Jun-Cheng; Wei, Yingqing; Ning, Shaobo; Yang, Xiuyan; Zhao, Mingzhu; Qiu, Yuran; Song, Kun; Yu, Zhengtian; Xu, Jianrong; Li, Xinyi; Lin, Houwen; Lu, Shaoyong; Zhang, Jian, Targeting a Cryptic Allosteric Site of Sirt6 with Small-Molecule Inhibitors That Inhibit the Migration of Pancreatic Cancer Cells. Acta Pharmaceutica Sinica B,2021, 10.1016/j.apsb.2021.06.015.

2.Xiong, Jiacheng; Xiang, Yusen; Huang, Ziming; Liu, Xiaohong; Wang, Mengge; Ge, Guangbo; Chen, Hongzhuan; Xu, Jianrong; Zheng, Mingyue; Chen, Lili, Structure-Based Virtual Screening and Identification of Potential Inhibitors of Sars-Cov-2 S-Rbd and Ace2 Interaction. Frontiers in Chemistry,2021, 9 (790), 740702. (Co-correspoding author)

3.Wang, Yi; Fang, Sui; Wu, Yan; Cheng, Xi; Zhang, Lei-Ke; Shen, Xu-Rui; Li, Shuang-Qu; Xu, Jian-Rong; Shang, Wei-Juan; Gao, Zhao-Bing; Xia, Bing-Qing, Discovery of Sars-Cov-2-E Channel Inhibitors as Antiviral Candidates. Acta Pharmacol Sin,2021, doi:10.1038/s41401-021-00732-2.

4.Song, Chenghuan; Shi, Jiyun; Xu, Jianrong; Zhao, Lanxue; Zhang, Yongfang; Huang, Wanying; Qiu, Yu; Zhang, Rui; Chen, Hongzhuan; Wang, Hao, Post‐Transcriptional Regulation of Α7 Nachr Expression by Mir‐98‐5p Modulates Cognition and Neuroinflammation in an Animal Model of Alzheimer's Disease. The FASEB Journal,2021, 35 (6), e21658.

5.Li, Huxiao; Xu, Jianrong; Li, Xiaotian; Hu, Yi; Liao, Yue; Zhou, Wei; Song, Zhongchen, Anti-Inflammatory Activity of Psoralen in Human Periodontal Ligament Cells Via Estrogen Receptor Signaling Pathway. Scientific Reports,2021, 11, 8754. (Co-1st author)

6.Jiang, Zhenla; Xu, Jianrong; Yan, Aixia; Wang, Ling, A Comprehensive Comparative Assessment of 3d Molecular Similarity Tools in Ligand-Based Virtual Screening. Brief Bioinform,2021, doi:10.1093/bib/bbab231.

7.Jia, Hao; Zhang, Ao; Yang, Yuquan; Cui, Yaqi; Xu, Jianrong; Jiang, Hewei; Tao, Shengce; Zhang, Dawei; Zeng, Heping; Hou, Zhaoyuan; Feng, Jijun, A Graphene Oxide Coated Tapered Microfiber Acting as a Super-Sensor for Rapid Detection of Sars-Cov-2. Lab on a Chip,2021, 21 (12), 2398-2406.

8.Ni, Liqiang; Chen, Lili; Huang, Xia; Han, Chouping; Xu, Jianrong; Zhang, Hong; Luan, Xin; Zhao, Yongfang; Xu, Jianguang; Yuan, Weian; Chen, Hongzhuan, Combating Covid-19 with Integrated Traditional Chinese and Western Medicine in China. Acta Pharmaceutica Sinica B,2020, 10 (7), 1149-1162.

9.Li, Miaomiao; Huang, Chen; Wu, Xingyu; Ding, Fan; Hu, Zhoumi; Zhu, Yan; Zhao, Lanxue; Hou, Lina; Chen, Hongzhuan; Wang, Hao; Xu, Jianrong; Tang, Dewei, The Optimization of a Novel Selective Antagonist for Human M(2) Muscarinic Acetylcholine Receptor. Bioorg Med Chem Lett,2020, 30 (24), 127632. (Co-correspoding author)

10.Gao, Fei; Zhai, Guanxing; Wang, Hui; Lu, Lu; Xu, Jianrong; Zhu, Jianwei; Chen, Daijie; Lu, Huili, Protective Effects of Anti-Alginate Monoclonal Antibody against Pseudomonas Aeruginosa Infection of Hela Cells. Microbial pathogenesis,2020, 145, 104240.

11.Xu, Jianrong; Tan, Panpan; Li, Hui; Cui, Yongyao; Qiu, Yu; Wang, Hao; Zhang, Xuan; Li, Juan; Zhu, Liang; Zhou, Wei; Chen, Hongzhuan, Direct Sumoylation of M1 Muscarinic Acetylcholine Receptor Increases Its Ligand-Binding Affinity and Signal Transduction. FASEB J,2019, 33 (3), 3237-3251. (Co-1st author)

12.Wang, Yu; Xia, Jia; Shen, Mengjun; Zhou, Yifan; Wu, Zhe; Shi, Yuhuan; Xu, Jianrong; Hou, Lina; Zhang, Rui; Qiu, Zhuibai; Xie, Qiong; Chen, Hongzhuan; Zhang, Yongfang; Wang, Hao, Effects of Bis-Mep on Reversing Amyloid Plaque Deposition and Spatial Learning and Memory Impairments in a Mouse Model of Beta-Amyloid Peptide- and Ibotenic Acid-Induced Alzheimer's Disease. Frontiers in aging neuroscience,2019, 11, 3.

13.Tao, Le; Ma, Wenting; Wu, Liu; Xu, Mingyi; Yang, Yanqin; Zhang, Wei; Sha, Wenjun; Li, Hongshan; Xu, Jianrong; Feng, Rilu; Xue, Dongying; Zhang, Jie; Dooley, Steven; Seki, Ekihiro; Liu, Ping; Liu, Cheng, Glial Cell Line-Derived Neurotrophic Factor (Gdnf) Mediates Hepatic Stellate Cell Activation Via Alk5/Smad Signalling. Gut,2019, 68, 2214-2227.

14.Luo, Yao; Zeng, Ranran; Guo, Qingqing; Xu, Jianrong; Sun, Xiaoou; Wang, Ling, Identifying a Novel Anticancer Agent with Microtubule-Stabilizing Effects through Computational Cell-Based Bioactivity Prediction Models and Bioassays. Organic & biomolecular chemistry,2019, 17 (6), 1519-1530.

15.Li, Liping; Zhang, Teng; Xu, Jianrong; Wu, Jing; Wang, Yida; Qiu, Xiran; Zhang, Yu; Hou, Weitong; Yan, Lan; An, Maomao; Jiang, Yuanying, The Synergism of the Small Molecule Enoblock and Fluconazole against Fluconazole-Resistant Candida Albicans. Front Microbiol,2019, 10, 2071.

16.Jiang, Min; Peng, Lei; Yang, Kai; Wang, Tianqi; Yan, Xueming; Jiang, Tao; Xu, Jianrong; Qi, Jin; Zhou, Hanbing; Qian, Niandong; Zhou, Qi; Chen, Bo; Xu, Xing; Deng, Lianfu; Yang, Chunhao, Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-Kappab Ligand (Rankl)-Receptor Activator of Nuclear Factor-Kappab (Rank) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization. Journal of medicinal chemistry,2019, 62 (11), 5370-5381.

17.Jian, Huahua; Xu, Guanpeng; Liu, Shunzhang; Hao, Yali; Meng, Canxing; Xu, Jianrong; Zhang, Yue; Liu, Xipeng; Xiao, Xiang, Multiple Mechanisms Are Involved in Repression of Filamentous Phage Sw1 Transcription by the DNA-Binding Protein Fpsr. Journal of molecular biology,2019, 431 (6), 1113-1126.

18.He, Xuan; Yang, Shuangshuang; Zhang, Rui; Hou, Lina; Xu, Jianrong; Hu, Yaer; Xu, Rang; Wang, Hao; Zhang, Yongfang, Smilagenin Protects Dopaminergic Neurons in Chronic Mptp/Probenecid-Lesioned Parkinson's Disease Models. Frontiers in cellular neuroscience,2019, 13, 18.

19.Guo, Qingqing; Luo, Yao; Zhai, Shiyang; Jiang, Zhenla; Zhao, Chongze; Xu, Jianrong; Wang, Ling, Discovery, Biological Evaluation, Structure-Activity Relationships and Mechanism of Action of Pyrazolo[3,4-B]Pyridin-6-One Derivatives as a New Class of Anticancer Agents. Organic & biomolecular chemistry,2019, 17 (25), 6201-6214.

20.Yang, Xiuyan; Zhong, Jie; Zhang, Qiufen; Qian, Jinxing; Song, Kun; Ruan, Cong; Xu, Jianrong; Ding, Ke; Zhang, Jian, Rational Design and Structure Validation of a Novel Peptide Inhibitor of the Adenomatous-Polyposis-Coli (Apc)-Rho-Guanine-Nucleotide-Exchange-Factor-4 (Asef) Interaction. Journal of medicinal chemistry,2018, 61 (17), 8017-8028.

21.Song, Huahua; Ma, Xinyi; Xu, Jianrong; Song, Qingxiang; Hu, Meng; Gu, Xiao; Zhang, Qian; Hou, Lina; Chen, Lepei; Huang, Yukun, The Shape Effect of Reconstituted High-Density Lipoprotein Nanocarriers on Brain Delivery and Aβ Clearance. Nano Research,2018, 11 (10), 5615–5628. (Co-1st author)

22.Shi, Yuhuan; Huang, Wanying; Wang, Yu; Zhang, Rui; Hou, Lina; Xu, Jianrong; Qiu, Zhuibai; Xie, Qiong; Chen, Hongzhuan; Zhang, Yongfang; Wang, Hao, Bis(9)-(-)-Meptazinol, a Novel Dual-Binding Ache Inhibitor, Rescues Cognitive Deficits and Pathological Changes in App/Ps1 Transgenic Mice. Translational neurodegeneration,2018, 7, 21.

23.Huang, Zhimin; Zhao, Junxing; Deng, Wei; Chen, Yingyi; Shang, Jialin; Song, Kun; Zhang, Lu; Wang, Chengxiang; Lu, Shaoyong; Yang, Xiuyan; He, Bin; Min, Jinrong; Hu, Hao; Tan, Minjia; Xu, Jianrong; Zhang, Qiufen; Zhong, Jie; Sun, Xiaoxiang; Mao, Zhiyong; Lin, Houwen; Xiao, Mingzhe; Chin, Y Eugene; Jiang, Hualiang; Xu, Ying; Chen, Guoqiang; Zhang, Jian, Identification of a Cellularly Active Sirt6 Allosteric Activator. Nature Chemical Biology,2018, 14 (12), 1118-1126.

24.Huang, Min; Song, Kun; Liu, Xinyi; Lu, Shaoyong; Shen, Qiancheng; Wang, Renxiao; Gao, Jingze; Hong, Yuanyuan; Li, Qian; Ni, Duan; Xu, Jianrong; Chen, Guoqiang; Zhang, Jian, Allofinder: A Strategy for Allosteric Modulator Discovery and Allosterome Analyses. Nucleic Acids Res,2018, 46 (W1), W451-W458.

25.Cao, Fangqi; Xu, Jianrong; Yan, Songmao; Yuan, Xiaoliang; Yang, Feiyu; Hou, Lina; Zhao, Lanxue; Zeng, Libo; Liu, Wenbin; Zhu, Liang; Chen, Hongzhuan, A Surface Plasmon Resonance-Based Inhibition Immunoassay for Forensic Determination of Methamphetamine in Human Serum. Forensic Chemistry,2018, 8, 21-27. (Co-1st & Co-correspoding author)

26.Zong, Huifang; Han, Lei; Ding, Kai; Wang, Jiaxian; Sun, Tao; Zhang, Xinyu; Cagliero, Cedric; Jiang, Hua; Xie, Yueqing; Xu, Jianrong; Zhang, Baohong; Zhu, Jianwei, Producing Defucosylated Antibodies with Enhanced in Vitro Antibody-Dependent Cellular Cytotoxicity Via Fut8 Knockout Cho-S Cells. Engineering in Life Sciences,2017, 17 (7), 801-808.

27.Zhao, Lan-Xue; Wang, Yan; Liu, Ting; Wang, Yan-Xia; Chen, Hong-Zhuan; Xu, Jian-Rong; Qiu, Yu, Alpha-Mangostin Decreases Beta-Amyloid Peptides Production Via Modulation of Amyloidogenic Pathway. CNS Neurosci Ther,2017, 23 (6), 526-534. (Co-correspoding author)

28.Zhang, T.; Li, J.; Yin, F.; Lin, B.; Wang, Z.; Xu, J.; Wang, H.; Zuo, D.; Wang, G.; Hua, Y.; Cai, Z., Toosendanin Demonstrates Promising Antitumor Efficacy in Osteosarcoma by Targeting Stat3. Oncogene,2017, 36 (47), 6627-6639.

29.Zhang, N.; Huang, H. J.; Tan, B. H.; Wei, Y. L.; Xiong, Q. Q.; Yan, Y.; Hou, L. L.; Wu, N. N.; Siwko, S.; Cimarelli, A.; Xu, J. R.; Han, H. H.; Qian, M.; Liu, M. Y.; Du, B., Leucine-Rich Repeat-Containing G Protein-Coupled Receptor 4 Facilitates Vesicular Stomatitis Virus Infection by Binding Vesicular Stomatitis Virus Glycoprotein. Journal of Biological Chemistry,2017, 292 (40), 16527-16538.

30.Li, J.; Yu, C.; Wang, R.; Xu, J.; Chi, Y.; Qin, J.; Liu, Q., The Omega-Carboxyl Group of 7-Ketocholesteryl-9-Carboxynonanoate Mediates the Binding of Oxldl to Cd36 Receptor and Enhances Caveolin-1 Expression in Macrophages. Int J Biochem Cell Biol,2017, 90, 121-135.

31.Li, J.; Gu, B. B.; Sun, F.; Xu, J. R.; Jiao, W. H.; Yu, H. B.; Han, B. N.; Yang, F.; Zhang, X. C.; Lin, H. W., Sesquiterpene Quinones/Hydroquinones from the Marine Sponge Spongia Pertusa Esper. Journal of natural products,2017, 80 (5), 1436-1445.

32.Deng, B.; Zhu, S.; Macklin, A. M.; Xu, J.; Lento, C.; Sljoka, A.; Wilson, D. J., Suppressing Allostery in Epitope Mapping Experiments Using Millisecond Hydrogen / Deuterium Exchange Mass Spectrometry. mAbs,2017, 9 (8), 1327-1336.

33.Zhang, Lin; Xiao, Jianfeng; Xu, Jianrong; Fu, Tianran; Cao, Zhiwei; Zhu, Liang; Chen, Hong-Zhuan; Shen, Xu; Jiang, Hualiang; Zhang, Liang, Crystal Structure of Fabz-Acp Complex Reveals a Dynamic Seesaw-Like Catalytic Mechanism of Dehydratase in Fatty Acid Biosynthesis. Cell Research,2016, 26 (12), 1330-1344.

34.Yang, Kai; Wang, Ming; Zhao, Yuzheng; Sun, Xuxu; Yang, Yi; Li, Xie; Zhou, Aiwu; Chu, Huilin; Zhou, Hu; Xu, Jianrong; Wu, Mian; Yang, Jie; Yi, Jing, A Redox Mechanism Underlying Nucleolar Stress Sensing by Nucleophosmin. Nature Communications,2016, 7, 13599.

35.Song, Qingxiang; Song, Huahua; Xu, Jianrong; Huang, Jialin; Hu, Meng; Gu, Xiao; Chen, Juan; Zheng, Gang; Chen, Hongzhuan; Gao, Xiaoling, Biomimetic Apoe-Reconstituted High Density Lipoprotein Nanocarrier for Blood-Brain Barrier Penetration and Amyloid Beta-Targeting Drug Delivery. Molecular Pharmaceutics,2016, 13 (11), 3976-3987.

36.Huang, Min; Chen, Zhongjie; Zhang, Lu; Huang, Zhimin; Chen, Yiying; Xu, Jianrong; Zhang, Jian; Shu, Xiaohong, Screening and Biological Evaluation of a Novel Stat3 Signaling Pathway Inhibitor against Cancer. Bioorganic & Medicinal Chemistry Letters,2016, 26 (21), 5172-5176.

37.Xu, Jianrong; Zhao, Hengyi; Zheng, Zhaoxi; Wang, Yu; Niu, Yinyao; Wang, Hao; Xu, Jun; Lu, Yang; Chen, Hongzhuan, Structural Determinants for the Interactions between Muscarinic Toxin 7 and Muscarinic Acetylcholine Receptors. Journal of Molecular Recognition,2015, 28 (4), 239-252. (1st author)

38.Hu, Hao; Rao, Zhigang; Feng, Min; Wu, Zhe; Xu, Jianrong; Chen, Hongzhuan; Liu, Peng; Xiao, Yuling; Hong, Xuechuan; Hu, Xianming, 3, 16-Bisquaternary Ammonium Steroid Derivatives as Neuromuscular Blocking Agents: Synthesis and Biological Evaluation. Steroids,2015, 96, 103-114.

39.Guan, Ying-Yun; Liu, Hai-Jun; Luan, Xin; Xu, Jian-Rong; Lu, Qin; Liu, Ya-Rong; Gao, Yun-Ge; Zhao, Mei; Chen, Hong-Zhuan; Fang, Chao, Raddeanin a, a Triterpenoid Saponin Isolated from Anemone Raddeana, Suppresses the Angiogenesis and Growth of Human Colorectal Tumor by Inhibiting Vegfr2 Signaling. Phytomedicine,2015, 22 (1), 103-110.

40.Zheng, Zhaoxi; Tang, Yabin; Lv, Haoyu; Xu, Jianrong; Zhao, Hengyi; Xie, Qiong; Qiu, Zhuibai; Chen, Hongzhuan; Wang, Hao, Determination of Meserine, a New Candidate for Alzheimer's Disease in Mice Brain by Liquid Chromatography-Tandem Mass Spectrometry and Its Application to a Pharmacokinetic and Tissue Distribution Study. Analytical and Bioanalytical Chemistry,2014, 406 (14), 3451-3458.

41.Song, Y.; Lu, H.; Xu, J.; Wang, X.; Zhou, W.; Hou, L.; Zhu, L.; Yu, Z.; Chen, H.; Cui, Y., Carbocysteine Restores Steroid Sensitivity by Targeting Histone Deacetylase 2 in a Thiol/Gsh-Dependent Manner. Pharmacology Research,2014, 91C, 88-98.

42.Qiu, Yu; Zhao, Wei; Wang, Yan; Xu, Jian-Rong; Huie, Eddie; Jiang, Shan; Yan, Ying-Hui; Loh, Horace H.; Chen, Hong-Zhuan; Law, Ping-Yee, Fk506-Binding Protein 12 Modulates Mu-Opioid Receptor Phosphorylation and Protein Kinase C Epsilon-Dependent Signaling by Its Direct Interaction with the Receptor. Molecular Pharmacology,2014, 85 (1), 37-49.

43.Luan, Xin; Gao, Yun-Ge; Guan, Ying-Yun; Xu, Jian-Rong; Lu, Qin; Zhao, Mei; Liu, Ya-Rong; Liu, Hai-Jun; Fang, Chao; Chen, Hong-Zhuan, Platycodin D Inhibits Tumor Growth by Antiangiogenic Activity Via Blocking Vegfr2-Mediated Signaling Pathway. Toxicology and Applied Pharmacology,2014, 281 (1), 118-124.

44.Hou, Li-Na; Xu, Jian-Rong; Zhao, Qing-Nan; Gao, Xiao-Ling; Cui, Yong-Yao; Xu, Jun; Wang, Hao; Chen, Hong-Zhuan, A New Motif in the N-Terminal of Acetylcholinesterase Triggers Amyloid-Beta Aggregation and Deposition. CNS Neuroscience & Therapeutics,2014, 20 (1), 59-66. (Co-1st author)

45.Guan, Ying-Yun; Luan, Xin; Xu, Jian-Rong; Liu, Ya-Rong; Lu, Qin; Wang, Chao; Liu, Hai-Jun; Gao, Yun-Ge; Chen, Hong-Zhuan; Fang, Chao, Selective Eradication of Tumor Vascular Pericytes by Peptide-Conjugated Nanoparticles for Antiangiogenic Therapy of Melanoma Lung Metastasis. Biomaterials,2014, 35 (9), 3060-3070.

46.Zhou, Dingshan; Tuo, Wei; Hu, Hao; Xu, Jianrong; Chen, Hongzhuan; Rao, Zhigang; Xiao, Yuling; Hu, Xianming; Liu, Peng, Synthesis and Activity Evaluation of Tilorone Analogs as Potential Anticancer Agents. European Journal of Medicinal Chemistry,2013, 64, 432-441.

47.Yu, Zhi-Hua; Xu, Jian-Rong; Wang, Yan-Xia; Xu, Guang-Ni; Xu, Zu-Peng; Yang, Kai; Wu, Da-Zheng; Cui, Yong-Yao; Chen, Hong-Zhuan, Targeted Inhibition of Kca3.1 Channel Attenuates Airway Inflammation and Remodeling in Allergic Asthma. American Journal of Respiratory Cell and Molecular Biology,2013, 48 (6), 685-693.

48.Xu, JianRong; Wang, Hao; Chen, HongZhuan, Muscarinic Acetylcholine Receptor Modulators Derived from Natural Toxins and Diverse Interaction Modes. Science China-Chemistry,2013, 56 (10), 1333-1343. (1st author)

49.Liu, Ting; Xia, Zheng; Zhang, Wei-Wei; Xu, Jian-rong; Ge, Xin-Xing; Li, Juan; Cui, Yongyao; Qiu, Zhui-Bai; Xu, Jun; Xie, Qiong; Wang, Hao; Chen, Hong-Zhuan, Bis(9)-(-)-nor-Meptazinol as a Novel Dual-Binding Achei Potently Ameliorates Scopolamine-Induced Cognitive Deficits in Mice. Pharmacology Biochemistry and Behavior,2013, 104, 138-143.

50.Xu, Jianrong; Xu, Jun; Chen, Hongzhuan, Structural Interpretation for the Subnanomolar Affinity of Muscarinic Toxin 7 for Human Muscarinic Acetylcholine Receptor 1 by Modeling Protein-Protein Interaction. Toxicon,2012, 60 (2), 102. (1st author)

51.Xu, Jianrong; Xu, Jun; Chen, Hongzhuan, Interpreting the Structural Mechanism of Action for Mt7 and Human Muscarinic Acetylcholine Receptor 1 Complex by Modeling Protein-Protein Interaction. Journal of Biomolecular Structure & Dynamics,2012, 30 (1), 30-44. (1st author)

52.Wang, Yan; Xia, Zheng; Xu, Jian-Rong; Wang, Yan-Xia; Hou, Li-Na; Qiu, Yu; Chen, Hong-Zhuan, Alpha-Mangostin, a Polyphenolic Xanthone Derivative from Mangosteen, Attenuates Beta-Amyloid Oligomers-Induced Neurotoxicity by Inhibiting Amyloid Aggregation. Neuropharmacology,2012, 62 (2), 871-881.

53.Hu, Hao; Rao, Zhigang; Xu, Jianrong; Zhu, Qingfu; Altenbach, Hans-Josef; Chen, Hongzhuan; Zhou, Dingshan; Xiao, Yuling; Ke, Xianbing; Guo, Hao; Wu, Zhongyuan; Liu, Peng; Hu, Xianming, 16-Morpholino Quaternary Ammonium Steroidal Derivatives as Neuromuscular Blocking Agents: Synthesis, Biological Evaluation and in Silico Probe of Ligand-Receptor Interaction. European Journal of Medicinal Chemistry,2012, 56, 332-347.

54.Bin, Deng; Jianrong, Xu; Zhiming, Wang; Yuxiu, Xiao, Single-Cell Analysis Using Capillary Electrophoresis. Progress in Chemistry,2010, 22 (11), 2215-2223.

55.Mei, J.; Xu, J. R.; Xiao, Y. X.; Zhang, Q. R.; Feng, Y. Q., Immobilized Phospholipid Capillary Electrophoresis for Study of Drug-Membrane Interactions and Prediction of Drug Activity. Talanta,2008, 75 (1), 104-10.

56.Mei, J.; Xu, J. R.; Xiao, Y. X.; Liao, X. Y.; Qiu, G. F.; Feng, Y. Q., A Novel Covalent Coupling Method for Coating of Capillaries with Liposomes in Capillary Electrophoresis. Electrophoresis,2008, 29 (18), 3825-33.

57.Jian-rong, XU; Yun-fei, WU; Yu-xiu, XIAO, Prediction for the Contents of Total Flavonoids and Triterpene Acids in Herba Glechomaes Based on Artificial Neural Network. Journal of Analytical Science,2007, 23 (3), 263-268. (1st author)