袁富文 特聘青年研究员

发布者：中西医发布时间：2022-06-16浏览次数：10

袁富文，特聘青年研究员，硕士生导师

电子邮箱：yuanfuwen@shutcm.edu.cn

办公室电话：(021) 5132-2501

通讯地址：浦东新区蔡伦路1200号创新科技楼4楼A418


    先后获得北京大学医学学士学位和心理学学士学位（双学位），博士师从北京大学童坦君院士从事衰老与肿瘤分子机理研究，获医学博士学位（获北京大学优秀博士毕业生）。博士后受训于美国Duke university School of Medicine，从事前列腺癌激素靶向治疗和基因编辑技术研究开发与运用。目前主要聚焦于利用生物信息学、多组学及分子生物学方法探究激素依赖性肿瘤的发病机制及其与衰老的关系，并开发基于基因编辑技术（CRISPR-Cas9/Cas13）和小分子靶向药的肿瘤治疗方案。


    获得美国国防部青年研究员奖（Early Investigator Research Award），主持美国国防部前列腺癌研究基金，参与多项中国国家自然科学基金和美国国立卫生研究院、国防部研究项目。目前已在Nucleic Acids Res., Aging Cell, Genes Dis., J Biol Chem.等国际刊物发表SCI论文近二十篇，其中九篇论文为第一作者，单篇最高影响因子大于>15，篇均影响因子>5。出版学术专著一部（入选“十三五”国家重点出版规划项目青年学者优秀学术专著文库），申请美国/欧洲发明专利一项。

 

研究方向：

  1. 中西医结合前列腺癌靶向治疗

  2. 基于CRISPR的基因编辑技术开发及在肿瘤中的应用

  3. 衰老与肿瘤的交互调控机制




Fuwen Yuan, Young Investigator, Master Mentor

Email：yuanfuwen@shutcm.edu.cn

TEL：(021) 5132-2501

 A418, 4/F, Innovation and Technology Building, 1200 Cailun Rd, Pudong, Shanghai


Yuan obtained medical bachelor's degree, psychology bachelor's degree (double major), and doctor of philosophy from Peking University, and is also the winner of the Outstanding Graduates of Peking University. During the Ph.D. period under the direction of professor Tong, Yuan focused on understanding the molecular connection between cellular senescence and cancer. He then moved to Duke University for postdoc. training and works on the molecular mechanism of prostate cancer targeted therapy and developing the CRISPR-based gene-editing technology. Yuan is now focusing on the molecular basis of hormone-dependent cancers and the connection with aging using multi-omics, bioinformatics, and molecular biology technologies. We are also interested in developing CRISPR-Cas9/Cas13-based gene editing systems and identifying small molecules for cancer therapy.


 Yuan received the Early Investigator Research Award from the United States Department of Defense (DOD) and was the principal investigator of a DOD grant for studying the CRISPR-Cas13-based technology for prostate cancer treatment. Yuan has published about twenty peer-reviewed papers including Nucleic Acids Res., Aging Cell, Genes Dis., J Biol Chem., and is also the chief editor of a monograph. Yuan is the co-inventor of a CRISPR-Cas13-based technical patent submitted to the US Patent Office and the European Patent Office.


Research Intersects：

  1. Targeted therapies for prostate cancer with integrative medicine

  2. To develop the CRISPR gene editing technologies for cancer treatment

  3. The molecular landscape between cancer and aging



Publications

  1. Yuan F, Hankey W, Wagner EJ, Li W, Wang Q*. Alternative polyadenylation of mRNA and its role in cancer. Genes & Diseases, 2021, 8(1): 61-72

  2. Yuan F, Hankey W, Wu D, Wang H, Somarelli J, Armstrong AJ, Huang J, Chen Z*, Wang Q*. Molecular determinants for enzalutamide-induced transcription in prostate cancer. Nucleic Acids Res., 2019, 47(19):10104-10114

  3. Yuan F, Xu C, Li G, Tong T*. Nucleolar TRF2 attenuated nucleolus stress-induced HCC cell-cycle arrest by altering rRNA synthesis. Cell Death & Disease. 2018, 9(5):518

  4. Yuan F, Tong T*. Cellular Senescence and Tumor Therapy. Progress in Biochemistry and Biophysics. 2018, Feb 2. doi: 10.16476/j.pibb.2017.0450

  5. Yuan F, Li G, Tong T*. Nucleolar and coiled-body phosphoprotein 1 (NOLC1) regulates the nucleolar retention of TRF2. Cell Death Discovery. 2017, 4 (3):17043

  6. Yuan F, Zhang Y, Ma L, Cheng Q, Li G, Tong T*. Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus. Aging Cell. 2017, 16(4):726-737

  7. Yuan F#, Cheng Q#, Li G, Tong T*. Nucleostemin Knockdown Sensitizes Hepatocellular Carcinoma Cells to Ultraviolet and Serum Starvation-Induced Apoptosis. PLoS One. 2015, 10(10): e0141678

  8. Yuan F, Cheng Q, Tong T*. The Impact of Nucleostemin siRNA on the Proliferation of HepG2 cells. Chinese Journal of Biochemistry and Molecular Biology. 2013, 29(11): 1041-1047

  9. Yuan F, Tong T*.Nucleolus Modulates the Shuttle of Telomere Components between Nucleolus and Telomere. J Tumor Res 2018, 4: 136

  10. Chen Zhong,Ye Z, Soccio RE, Nakadai T, Hankey W, Zhao Y, Huang F, Yuan F, Wang H, Cui Z, Sunkel B, Wu D, Dzeng RK, Thomas-Ahner JM, Huang THM, Clinton SK, Huang J, Lazar MA, Jin VX, Roeder RG, Wang Q. Phosphorylated MED1 links transcription recycling and cancer growth. Nucleic Acids Res. 2022, 50(8):4450-4463

  11. Cui ZF, Zeng C, Huang FR, Yuan FW, Yan JY, Zhao Y, Huang JT, Staats H, Everitt J, Sempowski G, Wang HY, Dong YZ*, Liu SL*, Wang QB*. Lung-selective Cas13d-based nanotherapy inhibits lethal SARS-CoV-2 infection by targeting host protease Ctsl. 2021, bioRxiv doi: https://doi.org/10.1101/2021.10.03.462915

  12.  Hankey W, Sunkel B, Yuan F, He H, Thomas-Ahner JM, Chen Z, Clinton SK, Huang J, Wang Q*. Prostate Cancer Cell Phenotypes Remain Stable Following PDE5 Inhibition in the Clinically Relevant Range.Transl Oncol. 2020, 13(9):100797

  13. Fu J, Huang D, Yuan F, Xie N, Li Q, Sun X, Zhou X, Li G, Tong T, Zhang Y*. TRAF-interacting protein with forkhead-associated domain (TIFA) transduces DNA damage-induced activation of NF-kB. Journal of Biological Chemistry. 2018 Mar 26. doi: 10.1074/jbc.RA117.001684.

  14. Xie N, Ma L, Zhu F, Zhao W, Tian F, Yuan F, Fu J, Huang D, Lv C, Tong T*. Regulation of the MDM2-p53 pathway by the nucleolar protein CSIG in response to nucleolar stress. Scientific Report. 2016, 6:36171.

  15. Ma L, Zhao W, Zhu F, Yuan F, Xie N, Li T, Wang P, Tong T*. Global Characteristics of CSIG-Associated Gene Expression Changes in Human HEK293 Cells and the Implications for CSIG Regulating Cell Proliferation and Senescence. Front Endocrinol (Lausanne). 2015, 6(69).

  16. Cheng Q, Yuan F, Lu F, Zhang B, Chen T, Chen X, Cheng Y, Li N, Ma L, Tong T*. CSIG promotes hepatocellular carcinoma proliferation by activating c-MYC expression. Oncotarget. 2015, 6(7): 4733-44.

  17. Cheng Q, Cao X, Yuan F, Li G, Tong T*.Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53. Biochem Biophys Res Commun. 2014, 448(3): 248-54.

  18. Cheng Q, Yuan F, Tong T*. Molecular Insights of c-Myc in Cellular Senescence. Progress in Biochemistry and Biophysics. 2014, 41 (3): 266-272.

  19. 袁富文 著. CSIG-NOLC1通路调控细胞衰老及肿瘤进程.ISBN 978-7-83014-022-9,中国学术期刊电子杂志社有限公司2021（入选“十三五”国家重点出版规划项目青年学者优秀学术专著文库）